Lehrstuhl für Molekulare Tierzucht und Biotechnologie
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2008-1989

Bauersachs S, Mitko K, Ulbrich SE, Blum H, Wolf E 2008 Transcriptome studies of bovine endometrium reveal molecular profiles characteristic for specific stages of estrous cycle and early pregnancy. Exp Clin Endocrinol Diabetes 116:371-384

Dahlhoff M, Horst D, Gerhard M, Kolligs FT, Wolf E, Schneider MR 2008 Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice. FEBS Lett 582:2911-2915

Gratao AA, Dahlhoff M, Sinowatz F, Wolf E, Schneider MR 2008 Betacellulin overexpression in the mouse ovary leads to MAPK3/MAPK1 hyperactivation and reduces litter size by impairing fertilization. Biol Reprod 78:43-52

Herbach N, Göke B, Wolf E, Wanke R 2008 Diets influence the diabetic phenotype of transgenic mice expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPRdn). Regul Pept 146:260-270

Jakob T, Köllisch GV, Howaldt M, Bewersdorff M, Rathkolb B, Müller ML, Sandholzer N, Nitschke L, Schiemann M, Mempel M, Ollert M, Neubauer A, Soewarto DA, Kremmer E, Ring J, Behrendt H, Flaswinkel H. 2008 Novel mouse mutants with primary cellular immunodeficiencies generated by genome-wide mutagenesis. J Allergy Clin Immunol. 121(1):179-184

Klymiuk N, Wolf E, Aigner B 2008 Concise classification of the genomic porcine endogenous retroviral gamma1 load to defined lineages. Virology 371:175-184

Lepikhov K, Zakhartchenko V, Hao R, Yang F, Wrenzycki C, Niemann H, Wolf E, Walter J 2008 Evidence for conserved DNA and histone H3 methylation reprogramming in mouse, bovine and rabbit zygotes. Epigenetics Chromatin 1:8

Lisse TS, Thiele F, Fuchs H, Hans W, Przemeck GK, Abe K, Rathkolb B, Quintanilla-Martinez L, Hoelzlwimmer G, Helfrich M, Wolf E, Ralston SH, Hrabe dA 2008 ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta. PLoS Genet 4:e7

Manolopoulou J, Bielohuby M, Caton SJ, Gomez-Sanchez CE, Renner-Mueller I, Wolf E, Lichtenauer UD, Beuschlein F, Hoeflich A, Bidlingmaier M 2008 A highly sensitive immunofluorometric assay for the measurement of aldosterone in small sample volumes: validation in mouse serum. J Endocrinol 196:215-224

Mitko K, Ulbrich SE, Wenigerkind H, Sinowatz F, Blum H, Wolf E, Bauersachs S 2008 Dynamic changes in messenger RNA profiles of bovine endometrium during the oestrous cycle. Reproduction 135:225-240

Puk O, Loster J, Dalke C, Soewarto D, Fuchs H, Budde B, Nurnberg P, Wolf E, de Angelis MH, Graw J 2008 Mutation in a novel connexin-like gene (Gjf1) in the mouse affects early lens development and causes a variable small-eye phenotype. Invest Ophthalmol Vis Sci 49:1525-1532

Reim NS, Breig B, Stahr K, Eberle J, Hoeflich A, Wolf E, Erben RG 2008 Cortical bone loss in androgen-deficient aged male rats is mainly caused by increased endocortical bone remodeling. J Bone Miner Res 23:694-704

Schneider MR, Wolf E, Braun J, Kolb HJ, Adler H 2008 Canine embryo-derived stem cells and models for human diseases. Hum Mol Genet 17:R42-R47

Schneider MR, Werner S, Paus R, Wolf E 2008 Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology. Am J Pathol 173:14-24

Schneider MR, Wolf E 2008 The epidermal growth factor receptor and its ligands in female reproduction: insights from rodent models. Cytokine Growth Factor Rev 19:173-181

Schneider MR, Antsiferova M, Feldmeyer L, Dahlhoff M, Bugnon P, Hasse S, Paus R, Wolf E, Werner S 2008 Betacellulin regulates hair follicle development and hair cycle induction and enhances angiogenesis in wounded skin. J Invest Dermatol 128:1256-1265

Schneider MR, Wolf E 2008 The epidermal growth factor receptor ligands at a glance. J Cell Physiol. 218(3):460-6

Schwab M, Kessler B, Wolf E, Jordan G, Mohl S, Winter G 2008 Correlation of in vivo and in vitro release data for rh-INFalpha lipid implants. Eur J Pharm Biopharm 70:690-694

Söker T, Dalke C, Puk O, Floss T, Becker L, Bolle I, Favor J, Hans W, Hoelter SM, Horsch M, Kallnik M, Kling E, Moerth C, Schrewe A, Stigloher C, Topp S, Gailus-Durner V, Naton B, Beckers J, Fuchs H, Ivandic B, Klopstock T, Schulz H, Wolf E, Wurst W, Bally-Cuif L, de Angelis MH, Graw J 2008 Pleiotropic effects in Eya3 knockout mice. BMC Dev Biol 8:118

Spencer TE, Sandra O, Wolf E 2008 Genes involved in conceptus-endometrial interactions in ruminants: insights from reductionism and thoughts on holistic approaches. Reproduction 135:165-179

von Waldthausen DC, Schneider MR, Renner-Müller I, Rauleder DN, Herbach N, Aigner B, Wanke R, Wolf E 2008 Systemic overexpression of growth hormone (GH) in transgenic FVB/N inbred mice: an optimized model for holistic studies of molecular mechanisms underlying GH-induced kidney pathology. Transgenic Res 17:479-488

Wöhr M, Dahlhoff M, Wolf E, Holsboer F, Schwarting RK, Wotjak CT 2008 Effects of genetic background, gender, and early environmental factors on isolation-induced ultrasonic calling in mouse pups: an embryo-transfer study. Behav Genet 38:579-595

Zuber C, Knackmuss S, Zemora G, Reusch U, Vlasova E, Diehl D, Mick V, Hoffmann K, Nikles D, Frohlich T, Arnold GJ, Brenig B, Wolf E, Lahm H, Little M, Weiss S 2008 Invasion of tumorigenic HT1080 cells is impeded by blocking or downregulating the 37-kDa/67-kDa laminin receptor. J Mol Biol 378:530-539

Aigner B, Rathkolb B, Mohr M, Klempt M, Hrabe dA, Wolf E 2007 Generation of ENU-induced mouse mutants with hypocholesterolemia: novel tools for dissecting plasma lipoprotein homeostasis. Lipids 42:731-737

Aigner B, Rathkolb B, Herbach N, Kemter E, Schessl C, Klaften M, Klempt M, de Angelis MH, Wanke R, Wolf E 2007 Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models. Am J Physiol Renal Physiol 292:F1560-F1567

Aigner B, Rathkolb B, Herbach N, Hrabe dA, Wanke R, Wolf E 2007 Diabetes models by screening for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects. Am J Physiol Endocrinol Metab 294:E232-E240

Bauersachs S, Mitko K, Blum H, Wolf E 2007 Technical note: Bovine oviduct and endometrium array version 1: a tailored tool for studying bovine endometrium biology and pathophysiology. J Dairy Sci 90:4420-4423

Bielohuby M, Herbach N, Wanke R, Maser-Gluth C, Beuschlein F, Wolf E, Hoeflich A 2007 Growth analysis of the mouse adrenal gland from weaning to adulthood: time- and gender-dependent alterations of cell size and number in the cortical compartment. Am J Physiol Endocrinol Metab 293:E139-E146

Habermann FA, Wuensch A, Sinowatz F, Wolf E 2007 Reporter genes for embryogenesis research in livestock species. Theriogenology 68 Suppl 1:S116-S124

Herbach N, Rathkolb B, Kemter E, Pichl L, Klaften M, de Angelis MH, Halban PA, Wolf E, Aigner B, Wanke R 2007 Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice. Diabetes 56:1268-1276

Kleger A, Busch T, Liebau S, Prelle K, Paschke S, Beil M, Rolletschek A, Wobus A, Wolf E, Adler G, Seufferlein T 2007 The bioactive lipid sphingosylphosphorylcholine induces differentiation of mouse embryonic stem cells and human promyelocytic leukaemia cells. Cell Signal 19:367-377

Moerth C, Schneider MR, Renner-Mueller I, Blutke A, Elmlinger MW, Erben RG, Camacho-Hubner C, Hoeflich A, Wolf E 2007 Postnatally elevated levels of insulin-like growth factor (IGF)-II fail to rescue the dwarfism of IGF-I-deficient mice except kidney weight. Endocrinology 148:441-451

Paula-Lopes FF, Boelhauve M, Habermann FA, Sinowatz F, Wolf E 2007 Leptin promotes meiotic progression and developmental capacity of bovine oocytes via cumulus cell-independent and -dependent mechanisms. Biol Reprod 76:532-541

Rubio-Aliaga I, Soewarto D, Wagner S, Klaften M, Fuchs H, Kalaydjiev S, Busch DH, Klempt M, Rathkolb B, Wolf E, Abe K, Zeiser S, Przemeck GK, Beckers J, Hrabe de Angelis M 2007 A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse. Genetics 175:1451-1463

Schneider MR, Adler H, Braun J, Kienzle B, Wolf E, Kolb HJ 2007 Canine embryo-derived stem cells--toward clinically relevant animal models for evaluating efficacy and safety of cell therapies. Stem Cells 25:1850-1851

Tennert C, Teupser D, Mueller MA, Wilfert W, Renner-Muller I, Stein O, Stein Y, Sippel AE, Wolf E, Thiery J 2007 Effect of macrophage ApoE on atherosclerosis in LDL-receptor deficient mice. Biochem Biophys Res Commun 361:574-579

Vujic Spasic M, Kiss J, Herrmann T, Kessler R, Stolte J, Galy B, Rathkolb B, Wolf E, Stremmel W, Hentze MW, Muckenthaler MU 2007 Physiologic systemic iron metabolism in mice deficient for duodenal Hfe. Blood 109:4511-4517

Wuensch A, Habermann FA, Kurosaka S, Klose R, Zakhartchenko V, Reichenbach HD, Sinowatz F, McLaughlin KJ, Wolf E 2007 Quantitative monitoring of pluripotency gene activation after somatic cloning in cattle. Biol Reprod 76:983-991

Yang F, Hao R, Kessler B, Brem G, Wolf E, Zakhartchenko V 2007 Rabbit somatic cell cloning: effects of donor cell type, histone acetylation status and chimeric embryo complementation. Reproduction 133:219-230

Barrantes IB, Montero-Pedrazuela A, Guadano-Ferraz A, Obregon MJ, Martinez dM, Gailus-Durner V, Fuchs H, Franz TJ, Kalaydjiev S, Klempt M, Holter S, Rathkolb B, Reinhard C, Morreale dE, Bernal J, Busch DH, Wurst W, Wolf E, Schulz H, Shtrom S, Greiner E, Hrabe dA, Westphal H, Niehrs C 2006 Generation and characterization of dickkopf3 mutant mice. Mol Cell Biol 26:2317-2326

Bauersachs S, Ulbrich SE, Gross K, Schmidt SE, Meyer HH, Wenigerkind H, Vermehren M, Sinowatz F, Blum H, Wolf E 2006 Embryo-induced transcriptome changes in bovine endometrium reveal species-specific and common molecular markers of uterine receptivity. Reproduction 132:319-331

Diehl D, Oesterle D, Elmlinger MW, Hoeflich A, Wolf E, Lahm H 2006 IGF-II transgenic mice display increased aberrant colon crypt multiplicity and tumor volume after 1,2-dimethylhydrazine treatment. J Carcinog 5:24

Ewerling S, Hofmann A, Klose R, Weppert M, Brem G, Rink K, Pfeifer A, Wolf E 2006 Evaluation of laser-assisted lentiviral transgenesis in bovine. Transgenic Res 15:447-454

Frey IM, Rubio-Aliaga I, Klempt M, Wolf E, Daniel H 2006 Phenotype analysis of mice deficient in the peptide transporter PEPT2 in response to alterations in dietary protein intake. Pflugers Arch 452:300-306

Hiendleder S, Wirtz M, Mund C, Klempt M, Reichenbach HD, Stojkovic M, Weppert M, Wenigerkind H, Elmlinger M, Lyko F, Schmitz OJ, Wolf E 2006 Tissue-specific effects of in vitro fertilization procedures on genomic cytosine methylation levels in overgrown and normal sized bovine fetuses. Biol Reprod 75:17-23

Hofmann A, Kessler B, Ewerling S, Kabermann A, Brem G, Wolf E, Pfeifer A 2006 Epigenetic regulation of lentiviral transgene vectors in a large animal model. Mol Ther 13:59-66

Klein C, Bauersachs S, Ulbrich SE, Einspanier R, Meyer HH, Schmidt SE, Reichenbach HD, Vermehren M, Sinowatz F, Blum H, Wolf E 2006 Monozygotic twin model reveals novel embryo-induced transcriptome changes of bovine endometrium in the preattachment period. Biol Reprod 74:253-264

Klempt M, Rathkolb B, Fuchs E, de Angelis MH, Wolf E, Aigner B 2006 Genotype-specific environmental impact on the variance of blood values in inbred and F1 hybrid mice. Mamm Genome 17:93-102

Kümin A, Huber C, Rulicke T, Wolf E, Werner S 2006 Peroxiredoxin 6 is a potent cytoprotective enzyme in the epidermis. Am J Pathol 169:1194-1205

Machado SA, Reichenbach HD, Weppert M, Wolf E, Goncalves PB 2006 The variability of ovum pick-up response and in vitro embryo production from monozygotic twin cows. Theriogenology 65:573-583

Rottmayer R, Ulbrich SE, Kolle S, Prelle K, Neumueller C, Sinowatz F, Meyer HH, Wolf E, Hiendleder S 2006 A bovine oviduct epithelial cell suspension culture system suitable for studying embryo-maternal interactions: morphological and functional characterization. Reproduction 132:637-648

Ulbrich SE, Rehfeld S, Bauersachs S, Wolf E, Rottmayer R, Hiendleder S, Vermehren M, Sinowatz F, Meyer HH, Einspanier R 2006 Region-specific expression of nitric oxide synthases in the bovine oviduct during the oestrous cycle and in vitro. J Endocrinol 188:205-213

Wolf E, Hiendleder S, Bauersachs S, Fröhlich T, Sinowatz F, Blum H, Arnold GJ 2006 [Methods for transcriptome and proteome research: applications for studying the biology of reproduction in cattle]. Berl Munch Tierarztl Wochenschr 119:7-16

Bauersachs S, Ulbrich SE, Gross K, Schmidt SE, Meyer HH, Einspanier R, Wenigerkind H, Vermehren M, Blum H, Sinowatz F, Wolf E 2005 Gene expression profiling of bovine endometrium during the oestrous cycle: detection of molecular pathways involved in functional changes. J Mol Endocrinol 34:889-908

Berendt FJ, Frohlich T, Schmidt SE, Reichenbach HD, Wolf E, Arnold GJ 2005 Holistic differential analysis of embryo-induced alterations in the proteome of bovine endometrium in the preattachment period. Proteomics 5:2551-2560

Boelhauve M, Sinowatz F, Wolf E, Paula-Lopes FF 2005 Maturation of bovine oocytes in the presence of leptin improves development and reduces apoptosis of in vitro-produced blastocysts. Biol Reprod 73:737-744

Diehl D, Lahm H, Wolf E, Bauersachs S 2005 Transcriptome analysis of a human colorectal cancer cell line shows molecular targets of insulin-like growth factor-binding protein-4 overexpression. Int J Cancer 113:588-599

Gailus-Durner V, Fuchs H, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Elvert R, Ehrhardt N, Dalke C, Franz TJ, Grundner-Culemann E, Hammelbacher S, Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A, Kalaydjiev SV, Klempt M, Kling E, Kunder S, Lengger C, Lisse T, Mijalski T, Naton B, Pedersen V, Prehn C, Przemeck G, Racz I, Reinhard C, Reitmeir P, Schneider I, Schrewe A, Steinkamp R, Zybill C, Adamski J, Beckers J, Behrendt H, Favor J, Graw J, Heldmaier G, Höfler H, Ivandic B, Katus H, Kirchhof P, Klingenspor M, Klopstock T, Lengeling A, Müller W, Ohl F, Ollert M, Quintanilla-Martinez L, Schmidt J, Schulz H, Wolf E, Wurst W, Zimmer A, Busch DH, de Angelis MH 2005 Introducing the German Mouse Clinic: open access platform for standardized phenotyping. Nat Methods 2:403-404

Graw J, Löster J, Puk O, Münster D, Haubst N, Soewarto D, Fuchs H, Meyer B, Nürnberg P, Pretsch W, Selby P, Favor J, Wolf E, Hrabe dA 2005 Three novel Pax6 alleles in the mouse leading to the same small-eye phenotype caused by different consequences at target promoters. Invest Ophthalmol Vis Sci 46:4671-4683

Herbach N, Goeke B, Schneider M, Hermanns W, Wolf E, Wanke R 2005 Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell development. Regul Pept 125:103-117

Hiendleder S, Bauersachs S, Boulesteix A, Blum H, Arnold GJ, Fröhlich T, Wolf E 2005 Functional genomics: tools for improving farm animal health and welfare. Rev Sci Tech 24:355-377

Hiendleder S, Zakhartchenko V, Wolf E 2005 Mitochondria and the success of somatic cell nuclear transfer cloning: from nuclear-mitochondrial interactions to mitochondrial complementation and mitochondrial DNA recombination. Reprod Fertil Dev 17:69-83

Kemter E, Philipp U, Klose R, Kuiper H, Boelhauve M, Distl O, Wolf E, Leeb T 2005 Molecular cloning, expression analysis and assignment of the porcine tumor necrosis factor superfamily member 10 gene (TNFSF10) to SSC13q34-->q36 by fluorescence in situ hybridization and radiation hybrid mapping. Cytogenet Genome Res 111:74-78

Kiepe D, Ciarmatori S, Hoeflich A, Wolf E, Tönshoff B 2005 Insulin-like growth factor (IGF)-I stimulates cell proliferation and induces IGF binding protein (IGFBP)-3 and IGFBP-5 gene expression in cultured growth plate chondrocytes via distinct signaling pathways. Endocrinology 146:3096-3104

Klose R, Kemter E, Bedke T, Bittmann I, Kessler B, Endres R, Pfeffer K, Schwinzer R, Wolf E 2005 Expression of biologically active human TRAIL in transgenic pigs. Transplantation 80:222-230

Rathkolb B, Tran TV, Klempt M, Hrabe dA, Wanke R, Wolf E, Aigner B 2005 Large-scale albuminuria screen for nephropathy models in chemically induced mouse mutants. Nephron Exp Nephrol 100:e143-e149

Schneider MR, Dahlhoff M, Herbach N, Renner-Mueller I, Dalke C, Puk O, Graw J, Wanke R, Wolf E 2005 Betacellulin overexpression in transgenic mice causes disproportionate growth, pulmonary hemorrhage syndrome, and complex eye pathology. Endocrinology 146:5237-5246

Schneider MR, Wolf E 2005 Genotyping of transgenic mice: old principles and recent developments. Anal Biochem 344:1-7

Shi Y, Reitmaier B, Regenbogen J, Slowey RM, Opalenik SR, Wolf E, Goppelt A, Davidson JM 2005 CARP, a cardiac ankyrin repeat protein, is up-regulated during wound healing and induces angiogenesis in experimental granulation tissue. Am J Pathol 166:303-312

Wolf E, Schneider MR, Zhou R, Fisch TM, Herbach N, Dahlhoff M, Wanke R, Hoeflich A 2005 Functional consequences of IGFBP excess - lessons from transgenic mice. Pediatr Nephrol 20:269-278

Bauersachs S, Rehfeld S, Ulbrich SE, Mallok S, Prelle K, Wenigerkind H, Einspanier R, Blum H, Wolf E 2004 Monitoring gene expression changes in bovine oviduct epithelial cells during the oestrous cycle. J Mol Endocrinol 32:449-466

Diehl D, Hoeflich A, Wolf E, Lahm H 2004 Insulin-like growth factor (IGF)-binding protein-4 inhibits colony formation of colorectal cancer cells by IGF-independent mechanisms. Cancer Res 64:1600-1603

Eckstein F, Weusten A, Schmidt C, Wehr U, Wanke R, Rambeck W, Wolf E, Mohan S 2004 Longitudinal in vivo effects of growth hormone overexpression on bone in transgenic mice. J Bone Miner Res 19:802-810

Fottner C, Hoeflich A, Wolf E, Weber MM 2004 Role of the insulin-like growth factor system in adrenocortical growth control and carcinogenesis. Horm Metab Res 36:397-405

Grosse-Hovest L, Müller S, Minoia R, Wolf E, Zakhartchenko V, Wenigerkind H, Lassnig C, Besenfelder U, Müller M, Lytton SD, Jung G, Brem G 2004 Cloned transgenic farm animals produce a bispecific antibody for T cell-mediated tumor cell killing. Proc Natl Acad Sci U S A 101:6858-6863

Hiendleder S, Bebbere D, Zakhartchenko V, Reichenbach HD, Wenigerkind H, Ledda S, Wolf E 2004 Maternal-fetal transplacental leakage of mitochondrial DNA in bovine nuclear transfer pregnancies: potential implications for offspring and recipients. Cloning Stem Cells 6:150-156

Hiendleder S, Mund C, Reichenbach HD, Wenigerkind H, Brem G, Zakhartchenko V, Lyko F, Wolf E 2004 Tissue-specific elevated genomic cytosine methylation levels are associated with an overgrowth phenotype of bovine fetuses derived by in vitro techniques. Biol Reprod 71:217-223

Hiendleder S, Prelle K, Bruggerhoff K, Reichenbach HD, Wenigerkind H, Bebbere D, Stojkovic M, Muller S, Brem G, Zakhartchenko V, Wolf E 2004 Nuclear-cytoplasmic interactions affect in utero developmental capacity, phenotype, and cellular metabolism of bovine nuclear transfer fetuses. Biol Reprod 70:1196-1205

Hoeflich A, Reisinger R, Schuett BS, Elmlinger MW, Russo VC, Vargas GA, Jehle PM, Lahm H, Renner-Muller I, Wolf E 2004 Peri/nuclear localization of intact insulin-like growth factor binding protein-2 and a distinct carboxyl-terminal IGFBP-2 fragment in vivo. Biochem Biophys Res Commun 324:705-710

Hoeflich A, Bunger L, Nedbal S, Renne U, Elmlinger MW, Blum WF, Bruley C, Kolb HJ, Wolf E 2004 Growth selection in mice reveals conserved and redundant expression patterns of the insulin-like growth factor system. Gen Comp Endocrinol 136:248-259

Hofmann A, Zakhartchenko V, Weppert M, Sebald H, Wenigerkind H, Brem G, Wolf E, Pfeifer A 2004 Generation of transgenic cattle by lentiviral gene transfer into oocytes. Biol Reprod 71:405-409

Kölle S, Stojkovic M, Reese S, Reichenbach HD, Wolf E, Sinowatz F 2004 Effects of growth hormone on the ultrastructure of bovine preimplantation embryos. Cell Tissue Res 317:101-108

Krampert M, Bloch W, Sasaki T, Bugnon P, Rulicke T, Wolf E, Aumailley M, Parks WC, Werner S 2004 Activities of the matrix metalloproteinase stromelysin-2 (MMP-10) in matrix degradation and keratinocyte organization in wounded skin. Mol Biol Cell 15:5242-5254

Lahm H, Andre S, Hoeflich A, Kaltner H, Siebert HC, Sordat B, der Lieth CW, Wolf E, Gabius HJ 2004 Tumor galectinology: insights into the complex network of a family of endogenous lectins. Glycoconj J 20:227-238

Leucht C, Vana K, Renner-Müller I, Dormont D, Lasmézas CI, Wolf E, Weiss S 2004 Knock-down of the 37-kDa/67-kDa laminin receptor in mouse brain by transgenic expression of specific antisense LRP RNA. Transgenic Res 13:81-85

Mohr M, Klempt M, Rathkolb B, de Angelis MH, Wolf E, Aigner B 2004 Hypercholesterolemia in ENU-induced mouse mutants. J Lipid Res 45:2132-2137

Shi W, Dirim F, Wolf E, Zakhartchenko V, Haaf T 2004 Methylation reprogramming and chromosomal aneuploidy in in vivo fertilized and cloned rabbit preimplantation embryos. Biol Reprod 71:340-347

Thorey IS, Hinz B, Hoeflich A, Kaesler S, Bugnon P, Elmlinger M, Wanke R, Wolf E, Werner S 2004 Transgenic mice reveal novel activities of growth hormone in wound repair, angiogenesis, and myofibroblast differentiation. J Biol Chem 279:26674-26684

Willer T, Prados B, Falcon-Perez JM, Renner-Muller I, Przemeck GK, Lommel M, Coloma A, Valero MC, de Angelis MH, Tanner W, Wolf E, Strahl S, Cruces J 2004 Targeted disruption of the Walker-Warburg syndrome gene Pomt1 in mouse results in embryonic lethality. Proc Natl Acad Sci U S A 101:14126-14131

Zhou R, Flaswinkel H, Schneider MR, Lahm H, Hoeflich A, Wanke R, Wolf E 2004 Insulin-like growth factor-binding protein-4 inhibits growth of the thymus in transgenic mice. J Mol Endocrinol 32:349-364

Bauersachs S, Blum H, Mallok S, Wenigerkind H, Rief S, Prelle K, Wolf E 2003 Regulation of ipsilateral and contralateral bovine oviduct epithelial cell function in the postovulation period: a transcriptomics approach. Biol Reprod 68:1170-1177

Dunant P, Larochelle N, Thirion C, Stucka R, Ursu D, Petrof BJ, Wolf E, Lochmuller H 2003 Expression of dystrophin driven by the 1.35-kb MCK promoter ameliorates muscular dystrophy in fast, but not in slow muscles of transgenic mdx mice. Mol Ther 8:80-89

Gilch S, Wopfner F, Renner-Muller I, Kremmer E, Bauer C, Wolf E, Brem G, Groschup MH, Schatzl HM 2003 Polyclonal anti-PrP auto-antibodies induced with dimeric PrP interfere efficiently with PrPSc propagation in prion-infected cells. J Biol Chem 278:18524-18531

Hiendleder S, Wolf E 2003 The mitochondrial genome in embryo technologies. Reprod Domest Anim 38:290-304

Hiendleder S, Zakhartchenko V, Wenigerkind H, Reichenbach HD, Bruggerhoff K, Prelle K, Brem G, Stojkovic M, Wolf E 2003 Heteroplasmy in bovine fetuses produced by intra- and inter-subspecific somatic cell nuclear transfer: neutral segregation of nuclear donor mitochondrial DNA in various tissues and evidence for recipient cow mitochondria in fetal blood. Biol Reprod 68:159-166

Hoeflich A, Fettscher O, Preta G, Lahm H, Kolb HJ, Wolf E, Weber MM 2003 Increased activity of catalase in tumor cells overexpressing IGFBP-2. Horm Metab Res 35:816-821

Hofmann A, Kessler B, Ewerling S, Weppert M, Vogg B, Ludwig H, Stojkovic M, Boelhauve M, Brem G, Wolf E, Pfeifer A 2003 Efficient transgenesis in farm animals by lentiviral vectors. EMBO Rep 4:1054-1060

Kölle S, Stojkovic M, Boie G, Wolf E, Sinowatz F 2003 Growth hormone-related effects on apoptosis, mitosis, and expression of connexin 43 in bovine in vitro maturation cumulus-oocyte complexes. Biol Reprod 68:1584-1589

Krebs O, Schreiner CM, Scott WJ, Jr., Bell SM, Robbins DJ, Goetz JA, Alt H, Hawes N, Wolf E, Favor J 2003 Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud. Development 130:6037-6047

Lahm H, Andre S, Hoeflich A, Fischer JR, Sordat B, Kaltner H, Wolf E, Gabius HJ 2003 Molecular biological fingerprinting of human lectin expression by RT-PCR. Methods Enzymol 362:287-297

Laurincik J, Schmoll F, Mahabir E, Schneider H, Stojkovic M, Zakhartchenko V, Prelle K, Hendrixen PJ, Voss PL, Moeszlacher GG, Avery B, Dieleman SJ, Besenfelder U, Muller M, Ochs RL, Wolf E, Schellander K, Maddox-Hyttel P 2003 Nucleolar proteins and ultrastructure in bovine in vivo developed, in vitro produced, and parthenogenetic cleavage-stage embryos. Mol Reprod Dev 65:73-85

Leheste JR, Melsen F, Wellner M, Jansen P, Schlichting U, Renner-Muller I, Andreassen TT, Wolf E, Bachmann S, Nykjaer A, Willnow TE 2003 Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect. FASEB J 17:247-249

Santos F, Zakhartchenko V, Stojkovic M, Peters A, Jenuwein T, Wolf E, Reik W, Dean W 2003 Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos. Curr Biol 13:1116-1121

Shi W, Hoeflich A, Flaswinkel H, Stojkovic M, Wolf E, Zakhartchenko V 2003 Induction of a senescent-like phenotype does not confer the ability of bovine immortal cells to support the development of nuclear transfer embryos. Biol Reprod 69:301-309

Shi W, Zakhartchenko V, Wolf E 2003 Epigenetic reprogramming in mammalian nuclear transfer. Differentiation 71:91-113

Stojkovic M, Krebs O, Kolle S, Prelle K, Assmann V, Zakhartchenko V, Sinowatz F, Wolf E 2003 Developmental regulation of hyaluronan-binding protein (RHAMM/IHABP) expression in early bovine embryos. Biol Reprod 68:60-66

Wolf E, Arnold GJ, Bauersachs S, Beier HM, Blum H, Einspanier R, Fröhlich T, Herrler A, Hiendleder S, Kölle S, Prelle K, Reichenbach HD, Stojkovic M, Wenigerkind H, Sinowatz F 2003 Embryo-maternal communication in bovine - strategies for deciphering a complex cross-talk. Reprod Domest Anim 38:276-289

Zeitz U, Weber K, Soegiarto DW, Wolf E, Balling R, Erben RG 2003 Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor. FASEB J 17:509-511

Zhou R, Diehl D, Hoeflich A, Lahm H, Wolf E 2003 IGF-binding protein-4: biochemical characteristics and functional consequences. J Endocrinol 178:177-193

Brüggerhoff K, Zakhartchenko V, Wenigerkind H, Reichenbach HD, Prelle K, Schernthaner W, Alberio R, Kuchenhoff H, Stojkovic M, Brem G, Hiendleder S, Wolf E 2002 Bovine somatic cell nuclear transfer using recipient oocytes recovered by ovum pick-up: effect of maternal lineage of oocyte donors. Biol Reprod 66:367-373

Eckstein F, Pavicic T, Nedbal S, Schmidt C, Wehr U, Rambeck W, Wolf E, Hoeflich A 2002 Insulin-like growth factor-binding protein-2 (IGFBP-2) overexpression negatively regulates bone size and mass, but not density, in the absence and presence of growth hormone/IGF-I excess in transgenic mice. Anat Embryol (Berl) 206:139-148

Eckstein F, Lochmuller EM, Koller B, Wehr U, Weusten A, Rambeck W, Hoeflich A, Wolf E 2002 Body composition, bone mass and microstructural analysis in GH-transgenic mice reveals that skeletal changes are specific to bone compartment and gender. Growth Horm IGF Res 12:116-125

Einspanier R, Schonfelder M, Muller K, Stojkovic M, Kosmann M, Wolf E, Schams D 2002 Expression of the vascular endothelial growth factor and its receptors and effects of VEGF during in vitro maturation of bovine cumulus-oocyte complexes (COC). Mol Reprod Dev 62:29-36

Graw J, Loster J, Soewarto D, Fuchs H, Reis A, Wolf E, Balling R, Hrabé de Angelis M 2002 V76D mutation in a conserved gD-crystallin region leads to dominant cataracts in mice. Mamm Genome 13:452-455

Hoeflich A, Weber MM, Fisch T, Nedbal S, Fottner C, Elmlinger MW, Wanke R, Wolf E 2002 Insulin-like growth factor binding protein 2 (IGFBP-2) separates hypertrophic and hyperplastic effects of growth hormone (GH)/IGF-I excess on adrenocortical cells in vivo. FASEB J 16:1721-1731

Hoeflich A, Reisinger R, Vargas GA, Elmlinger MW, Schuett B, Jehle PM, Renner-Muller I, Lahm H, Russo VC, Wolf E 2002 Mutation of the RGD sequence does not affect plasma membrane association and growth inhibitory effects of elevated IGFBP-2 in vivo. FEBS Lett 523:63-67

Kölle S, Stojkovic M, Boie G, Wolf E, Sinowatz F 2002 Growth hormone inhibits apoptosis in in vitro produced bovine embryos. Mol Reprod Dev 61:180-186

Lahm H, Gittner K, Krebs O, Sprague L, Deml E, Oesterle D, Hoeflich A, Wanke R, Wolf E 2002 Diethylnitrosamine induces long-lasting re-expression of insulin-like growth factor II during early stages of liver carcinogenesis in mice. Growth Horm IGF Res 12:69-79

Laurincik J, Zakhartchenko V, Stojkovic M, Brem G, Wolf E, Muller M, Ochs RL, Maddox-Hyttel P 2002 Nucleolar protein allocation and ultrastructure in bovine embryos produced by nuclear transfer from granulosa cells. Mol Reprod Dev 61:477-487

Motlik J, Alberio R, Zakhartchenko V, Stojkovic M, Kubelka M, Wolf E 2002 The effect of activation of mammalian oocytes on remodeling of donor nuclei after nuclear transfer. Cloning Stem Cells 4:245-252

Ott M, Schernthaner W, Sinowatz F, Wolf E 2002 Effects of bovine serum albumin and estrous cow serum on development and ultrastructure of in vitro-produced porcine embryos. Anat Histol Embryol 31:151-157

Prelle K, Zink N, Wolf E 2002 Pluripotent stem cells--model of embryonic development, tool for gene targeting, and basis of cell therapy. Anat Histol Embryol 31:169-186

Prelle K, Zakhartchenko V, Wolf E 2002 [Application of stem cell technology and nuclear transfer in animal models]. Z Ärztl Fortbild Qualitatssich 96:434-440

Rief S, Sinowatz F, Stojkovic M, Einspanier R, Wolf E, Prelle K 2002 Effects of a novel co-culture system on development, metabolism and gene expression of bovine embryos produced in vitro. Reproduction 124:543-556

Schneider MR, Wolf E, Hoeflich A, Lahm H 2002 IGF-binding protein-5: flexible player in the IGF system and effector on its own. J Endocrinol 172:423-440

Stojkovic M, Kolle S, Peinl S, Stojkovic P, Zakhartchenko V, Thompson JG, Wenigerkind H, Reichenbach HD, Sinowatz F, Wolf E 2002 Effects of high concentrations of hyaluronan in culture medium on development and survival rates of fresh and frozen-thawed bovine embryos produced in vitro. Reproduction 124:141-153

Wolf E 2002 Cloning of animals - perspectives for biomedical research. Exp Toxicol Pathol 54:161-162

Alberio R, Zakhartchenko V, Motlik J, Wolf E 2001 Mammalian oocyte activation: lessons from the sperm and implications for nuclear transfer. Int J Dev Biol 45:797-809

Alberio R, Brero A, Motlik J, Cremer T, Wolf E, Zakhartchenko V 2001 Remodeling of donor nuclei, DNA-synthesis, and ploidy of bovine cumulus cell nuclear transfer embryos: effect of activation protocol. Mol Reprod Dev 59:371-379

Alessandrini F, Jakob T, Wolf A, Wolf E, Balling R, Hrabe dA, Ring J, Behrendt H 2001 ENU mouse mutagenesis: generation of mouse mutants with aberrant plasma IgE levels. Int Arch Allergy Immunol 124:25-28

Brockmann GA, Haley CS, Wolf E, Karle S, Kratzsch J, Renne U, Schwerin M, Hoeflich A 2001 Genome-wide search for loci controlling serum IGF binding protein levels of mice. FASEB J 15:978-987

Dean W, Santos F, Stojkovic M, Zakhartchenko V, Walter J, Wolf E, Reik W 2001 Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos. Proc Natl Acad Sci U S A 98:13734-13738

Freistedt P, Stojkovic P, Wolf E, Stojkovic M 2001 Energy status of nonmatured and in vitro-matured domestic cat oocytes and of different stages of in vitro-produced embryos: enzymatic removal of the zona pellucida increases adenosine triphosphate content and total cell number of blastocysts. Biol Reprod 65:793-798

Freistedt P, Stojkovic M, Wolf E 2001 Efficient in vitro production of cat embryos in modified synthetic oviduct fluid medium: effects of season and ovarian status. Biol Reprod 65:9-13

Graw J, Loster J, Soewarto D, Fuchs H, Meyer B, Reis A, Wolf E, Balling R, Hrabé de Angelis M 2001 Characterization of a mutation in the lens-specific MP70 encoding gene of the mouse leading to a dominant cataract. Exp Eye Res 73:867-876

Graw J, Loster J, Soewarto D, Fuchs H, Meyer B, Reis A, Wolf E, Balling R, Hrabé de Angelis M 2001 Characterization of a new, dominant V124E mutation in the mouse alphaA-crystallin-encoding gene. Invest Ophthalmol Vis Sci 42:2909-2915

Graw J, Loster J, Soewarto D, Fuchs H, Reis A, Wolf E, Balling R, Hrabé de Angelis M 2001 Aey2, a new mutation in the betaB2-crystallin-encoding gene of the mouse. Invest Ophthalmol Vis Sci 42:1574-1580

Graw J, Klopp N, Loster J, Soewarto D, Fuchs H, Becker-Follmann J, Reis A, Wolf E, Balling R, Habré de Angelis M 2001 Ethylnitrosourea-induced mutation in mice leads to the expression of a novel protein in the eye and to dominant cataracts. Genetics 157:1313-1320

Hirai M, Boersma A, Hoeflich A, Wolf E, Foll J, Aumüller TR, Braun J 2001 Objectively measured sperm motility and sperm head morphometry in boars (Sus scrofa): relation to fertility and seminal plasma growth factors. J Androl 22:104-110

Hoeflich A, Reisinger R, Lahm H, Kiess W, Blum WF, Kolb HJ, Weber MM, Wolf E 2001 Insulin-like growth factor-binding protein 2 in tumorigenesis: protector or promoter? Cancer Res 61:8601-8610

Hoeflich A, Nedbal S, Blum WF, Erhard M, Lahm H, Brem G, Kolb HJ, Wanke R, Wolf E 2001 Growth inhibition in giant growth hormone transgenic mice by overexpression of insulin-like growth factor-binding protein-2. Endocrinology 142:1889-1898

Hyttel P, Laurincik J, Zakhartchenko V, Stojkovic M, Wolf E, Müller M, Ochs RL, Brem G 2001 Nucleolar protein allocation and ultrastructure in bovine embryos produced by nuclear transfer from embryonic cells. Cloning 3:69-82

Kölle S, Stojkovic M, Prelle K, Waters M, Wolf E, Sinowatz F 2001 Growth hormone (GH)/GH receptor expression and GH-mediated effects during early bovine embryogenesis. Biol Reprod 64:1826-1834

Lahm H, Andre S, Hoeflich A, Fischer JR, Sordat B, Kaltner H, Wolf E, Gabius HJ 2001 Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures. J Cancer Res Clin Oncol 127:375-386

Lochmüller EM, Jung V, Weusten A, Wehr U, Wolf E, Eckstein F 2001 Precision of high-resolution dual energy X-ray absorptiometry of bone mineral status and body composition in small animal models. Eur Cell Mater 1:43-51

Nalbantoglu J, Larochelle N, Wolf E, Karpati G, Lochmuller H, Holland PC 2001 Muscle-specific overexpression of the adenovirus primary receptor CAR overcomes low efficiency of gene transfer to mature skeletal muscle. J Virol 75:4276-4282

Prelle K, Stojkovic M, Boxhammer K, Motlik J, Ewald D, Arnold GJ, Wolf E 2001 Insulin-like growth factor I (IGF-I) and long R(3)IGF-I differently affect development and messenger ribonucleic acid abundance for IGF-binding proteins and type I IGF receptors in in vitro produced bovine embryos. Endocrinology 142:1309-1316

Schneider MR, Zhou R, Hoeflich A, Krebs O, Schmidt J, Mohan S, Wolf E, Lahm H 2001 Insulin-like growth factor-binding protein-5 inhibits growth and induces differentiation of mouse osteosarcoma cells. Biochem Biophys Res Commun 288:435-442

Stojkovic M, Machado SA, Stojkovic P, Zakhartchenko V, Hutzler P, Goncalves PB, Wolf E 2001 Mitochondrial distribution and adenosine triphosphate content of bovine oocytes before and after in vitro maturation: correlation with morphological criteria and developmental capacity after in vitro fertilization and culture. Biol Reprod 64:904-909

Thorey IS, Roth J, Regenbogen J, Halle JP, Bittner M, Vogl T, Kaesler S, Bugnon P, Reitmaier B, Durka S, Graf A, Wockner M, Rieger N, Konstantinow A, Wolf E, Goppelt A, Werner S 2001 The Ca2+-binding proteins S100A8 and S100A9 are encoded by novel injury-regulated genes. J Biol Chem 276:35818-35825

Wanke R, Wolf E, Brem G, Hermanns W 2001 [Role of podocyte damage in the pathogenesis of glomerulosclerosis and tubulointerstitial lesions: findings in the growth hormone transgenic mouse model of progressive nephropathy]. Verh Dtsch Ges Pathol 85:250-256

Wankell M, Munz B, Hubner G, Hans W, Wolf E, Goppelt A, Werner S 2001 Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis. EMBO J 20:5361-5372

Zakhartchenko V, Mueller S, Alberio R, Schernthaner W, Stojkovic M, Wenigerkind H, Wanke R, Lassnig C, Mueller M, Wolf E, Brem G 2001 Nuclear transfer in cattle with non-transfected and transfected fetal or cloned transgenic fetal and postnatal fibroblasts. Mol Reprod Dev 60:362-369

Alberio R, Motlik J, Stojkovic M, Wolf E, Zakhartchenko V 2000 Behavior of M-phase synchronized blastomeres after nuclear transfer in cattle. Mol Reprod Dev 57:37-47

Alberio R, Kubelka M, Zakhartchenko V, Hajduch M, Wolf E, Motlik J 2000 Activation of bovine oocytes by specific inhibition of cyclin-dependent kinases. Mol Reprod Dev 55:422-432

Flaswinkel H, Alessandrini F, Rathkolb B, Decker T, Kremmer E, Servatius A, Jakob T, Soewarto D, Marschall S, Fella C, Behrendt H, Ring J, Wolf E, Balling R, Hrabé de Angelis M, Pfeffer K 2000 Identification of immunological relevant phenotypes in ENU mutagenized mice. Mamm Genome 11:526-527

Fuchs H, Schughart K, Wolf E, Balling R, Hrabé de Angelis M 2000 Screening for dysmorphological abnormalities--a powerful tool to isolate new mouse mutants. Mamm Genome 11:528-530

Hoeflich A, Fettscher O, Lahm H, Blum WF, Kolb HJ, Engelhardt D, Wolf E, Weber MM 2000 Overexpression of insulin-like growth factor-binding protein-2 results in increased tumorigenic potential in Y-1 adrenocortical tumor cells. Cancer Res 60:834-838

Hrabé de Angelis MH, Flaswinkel H, Fuchs H, Rathkolb B, Soewarto D, Marschall S, Heffner S, Pargent W, Wuensch K, Jung M, Reis A, Richter T, Alessandrini F, Jakob T, Fuchs E, Kolb H, Kremmer E, Schaeble K, Rollinski B, Roscher A, Peters C, Meitinger T, Strom T, Steckler T, Holsboer F, Klopstock T, Gekeler F, Schindewolf C, Jung T, Avraham K, Behrendt H, Ring J, Zimmer A, Schughart K, Pfeffer K, Wolf E, Balling R 2000 Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet 25:444-447

Hyttel P, Laurincik J, Viuff D, Fair T, Zakhartchenko V, Rosenkranz C, Avery B, Rath D, Niemann H, Thomsen PD, Schellander K, Callesen H, Wolf E, Ochs RL, Greve T 2000 Activation of ribosomal RNA genes in preimplantation cattle and swine embryos. Anim Reprod Sci 60-61:49-60

Lahm H, Hoeflich A, Andre S, Sordat B, Kaltner H, Wolf E, Gabius HJ 2000 Gene expression of galectin-9/ecalectin, a potent eosinophil chemoattractant, and/or the insertional isoform in human colorectal carcinoma cell lines and detection of frame-shift mutations for protein sequence truncations in the second functional lectin domain. Int J Oncol 17:519-524

Lipp M, Förster R, Schubel A, Burgstahler R, Müller G, Breitfeld D, Kremmer E, Wolf E 2000 Functional organization of secondary lymphoid organs by homeostatic chemokines. Eur Cytokine Netw 11:504-505

Lipp M, Burgstahler R, Müller G, Pevzner V, Kremmer E, Wolf E, Förster R 2000 Functional organization of secondary lymphoid organs by the chemokine system. Curr Top Microbiol Immunol 251:173-179

Prelle K, Wobus AM, Krebs O, Blum WF, Wolf E 2000 Overexpression of insulin-like growth factor-II in mouse embryonic stem cells promotes myogenic differentiation. Biochem Biophys Res Commun 277:631-638

Rathkolb B, Fuchs E, Kolb HJ, Renner-Müller I, Krebs O, Balling R, Hrabé de Angelis M, Wolf E 2000 Large-scale N-ethyl-N-nitrosourea mutagenesis of mice - from phenotypes to genes. Exp Physiol 85:635-644

Rathkolb B, Decker T, Fuchs E, Soewarto D, Fella C, Heffner S, Pargent W, Wanke R, Balling R, Hrabé de Angelis M, Kolb HJ, Wolf E 2000 The clinical-chemical screen in the Munich ENU Mouse Mutagenesis Project: screening for clinically relevant phenotypes. Mamm Genome 11:543-546

Reichart U, Renner-Müller I, Höflich A, Müller OJ, Franz WM, Wolf E, Müller M, Brem G, Aigner B 2000 Contrasting obesity phenotypes uncovered by partial leptin receptor gene deletion in transgenic mice. Biochem Biophys Res Commun 269:502-507

Reichart U, Kappler R, Scherthan H, Wolf E, Müller M, Brem G, Aigner B 2000 Partial leptin receptor gene deletion in transgenic mice prevents expression of the membrane-bound isoforms except for Ob-Rc. Biochem Biophys Res Commun 269:496-501

Rolinski B, Arnecke R, Dame T, Kreischer J, Olgemöller B, Wolf E, Balling R, Hrabé de Angelis M, Roscher AA 2000 The biochemical metabolite screen in the Munich ENU Mouse Mutagenesis Project: determination of amino acids and acylcarnitines by tandem mass spectrometry. Mamm Genome 11:547-551

Schneider MR, Hoeflich A, Fischer JR, Wolf E, Sordat B, Lahm H 2000 Interleukin-6 stimulates clonogenic growth of primary and metastatic human colon carcinoma cells. Cancer Lett 151:31-38

Schneider MR, Lahm H, Wu M, Hoeflich A, Wolf E 2000 Transgenic mouse models for studying the functions of insulin-like growth factor-binding proteins. FASEB J 14:629-640

Soewarto D, Fella C, Teubner A, Rathkolb B, Pargent W, Heffner S, Marschall S, Wolf E, Balling R, Hrabé de Angelis M 2000 The large-scale Munich ENU-mouse-mutagenesis screen. Mamm Genome 11:507-510

Steinborn R, Schinogl P, Zakhartchenko V, Achmann R, Schernthaner W, Stojkovic M, Wolf E, Müller M, Brem G 2000 Mitochondrial DNA heteroplasmy in cloned cattle produced by fetal and adult cell cloning. Nat Genet 25:255-257

Suttner R, Zakhartchenko V, Stojkovic P, Müller S, Alberio R, Medjugorac I, Brem G, Wolf E, Stojkovic M 2000 Intracytoplasmic sperm injection in bovine: effects of oocyte activation, sperm pretreatment and injection technique. Theriogenology 54:935-948

von Wichert G, Jehle PM, Hoeflich A, Koschnick S, Dralle H, Wolf E, Wiedenmann B, Boehm BO, Adler G, Seufferlein T 2000 Insulin-like growth factor-I is an autocrine regulator of chromogranin A secretion and growth in human neuroendocrine tumor cells. Cancer Res 60:4573-4581

Weber MM, Fottner C, Wolf E 2000 The role of the insulin-like growth factor system in adrenocortical tumourigenesis. Eur J Clin Invest 30 Suppl 3:69-75

Wobus AM, Wolf E, Beier HM 2000 Embryonic stem cells and nuclear transfer strategies. Present state and future prospects. Cells Tissues Organs 166:1-5

Wolf E, Schernthaner W, Zakhartchenko V, Prelle K, Stojkovic M, Brem G 2000 Transgenic technology in farm animals--progress and perspectives. Exp Physiol 85:615-625

Wolf E, Lahm H, Wu M, Wanke R, Hoeflich A 2000 Effects of IGFBP-2 overexpression in vitro and in vivo. Pediatr Nephrol 14:572-578

Aigner B, Pambalk K, Reichart U, Besenfelder U, Bosze Z, Renner M, Gunzburg WH, Wolf E, Muller M, Brem G 1999 Species-specific alternative splicing of transgenic RNA in the mammary glands of pigs, rabbits, and mice. Biochem Biophys Res Commun 257:843-850

Forster R, Schubel A, Breitfeld D, Kremmer E, Renner-Muller I, Wolf E, Lipp M 1999 CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99:23-33

Graichen H, Lochmuller EM, Wolf E, Langkabel B, Stammberger T, Haubner M, Renner-Muller I, Englmeier KH, Eckstein F 1999 A non-destructive technique for 3-D microstructural phenotypic characterisation of bones in genetically altered mice: preliminary data in growth hormone transgenic animals and normal controls. Anat Embryol (Berl) 199:239-248

Graw J, Jung M, Loster J, Klopp N, Soewarto D, Fella C, Fuchs H, Reis A, Wolf E, Balling R, Hrabé de Angelis M. 1999 Mutation in the betaA3/A1-crystallin encoding gene Cryba1 causes a dominant cataract in the mouse. Genomics 62:67-73

Hoeflich A, Wu M, Mohan S, Föll J, Wanke R, Froehlich T, Arnold GJ, Lahm H, Kolb HJ, Wolf E 1999 Overexpression of insulin-like growth factor-binding protein-2 in transgenic mice reduces postnatal body weight gain. Endocrinology 140:5488-5496

Hoeflich A, Reichenbach HD, Schwartz J, Grupp T, Weber MM, Foll J, Wolf E 1999 Insulin-like growth factors and IGF-binding proteins in bovine seminal plasma. Domest Anim Endocrinol 17:39-51

Jehle PM, Fussgaenger RD, Blum WF, Angelus NK, Hoeflich A, Wolf E, Jungwirth RJ 1999 Differential autocrine regulation of intestine epithelial cell proliferation and differentiation by insulin-like growth factor (IGF) system components. Horm Metab Res 31:97-102

Kiess W, Paquette J, Koepf G, Wolf E, Deal C 1999 Proinsulin-like growth factor-II overexpression does not alter monoallelic H19 gene expression in transfected human embryonic kidney fibroblasts. Biochem Biophys Res Commun 255:226-230

Lochmüller EM, Weusten A, Wolf E, Cindik E, Renner-Müller I, Eikmeier T, Eckstein F 1999 [Sex-specific analysis of bone mass in normal and growth hormone transgenic mice using dual energy x-ray absorptiometry (DXA)]. Ann Anat 181:191-198

Mueller S, Prelle K, Rieger N, Petznek H, Lassnig C, Luksch U, Aigner B, Baetscher M, Wolf E, Mueller M, Brem G 1999 Chimeric pigs following blastocyst injection of transgenic porcine primordial germ cells. Mol Reprod Dev 54:244-254

Prelle K, Vassiliev IM, Vassilieva SG, Wolf E, Wobus AM 1999 Establishment of pluripotent cell lines from vertebrate species--present status and future prospects. Cells Tissues Organs 165:220-236

Reischl J, Prelle K, Schol H, Neumüller C, Einspanier R, Sinowatz F, Wolf E 1999 Factors affecting proliferation and dedifferentiation of primary bovine oviduct epithelial cells in vitro. Cell Tissue Res 296:371-383

Schernthaner W, Wenigerkind H, Stojkovic M, Palma GA, Mödl J, Wolf E, Brem G 1999 Pregnancy rate after ultrasound-guided follicle aspiration in nonlactating cows from different breeds. Zentralbl Veterinarmed A 46:33-37

Stojkovic M, Westesen K, Zakhartchenko V, Stojkovic P, Boxhammer K, Wolf E 1999 Coenzyme Q(10) in submicron-sized dispersion improves development, hatching, cell proliferation, and adenosine triphosphate content of in vitro-produced bovine embryos. Biol Reprod 61:541-547

Stojkovic M, Büttner M, Zakhartchenko V, Riedl J, Reichenbach HD, Wenigerkind H, Brem G, Wolf E 1999 Secretion of interferon-tau by bovine embryos in long-term culture: comparison of in vivo derived, in vitro produced, nuclear transfer and demi-embryos. Anim Reprod Sci 55:151-162

Wanke R, Milz S, Rieger N, Ogiolda L, Renner-Müller I, Brem G, Hermanns W, Wolf E 1999 Overgrowth of skin in growth hormone transgenic mice depends on the presence of male gonads. J Invest Dermatol 113:967-971

Weber MM, Fottner C, Schmidt P, Brodowski KM, Gittner K, Lahm H, Engelhardt D, Wolf E 1999 Postnatal overexpression of insulin-like growth factor II in transgenic mice is associated with adrenocortical hyperplasia and enhanced steroidogenesis. Endocrinology 140:1537-1543

Wolf E, Schernthaner W, Müller S, Brem G 1999 [Xenotransplantation. Possibilities of animal breeding]. Zentralbl Chir 124:585-590

Zakhartchenko V, Alberio R, Stojkovic M, Prelle K, Schernthaner W, Stojkovic P, Wenigerkind H, Wanke R, Duchler M, Steinborn R, Mueller M, Brem G, Wolf E 1999 Adult cloning in cattle: potential of nuclei from a permanent cell line and from primary cultures. Mol Reprod Dev 54:264-272

Zakhartchenko V, Durcova-Hills G, Stojkovic M, Schernthaner W, Prelle K, Steinborn R, Müller M, Brem G, Wolf E 1999 Effects of serum starvation and re-cloning on the efficiency of nuclear transfer using bovine fetal fibroblasts. J Reprod Fertil 115:325-331

Zakhartchenko V, Durcova-Hills G, Schernthaner W, Stojkovic M, Reichenbach HD, Mueller S, Steinborn R, Mueller M, Wenigerkind H, Prelle K, Wolf E, Brem G 1999 Potential of fetal germ cells for nuclear transfer in cattle. Mol Reprod Dev 52:421-426

Bieser B, Stojkovic M, Wolf E, Meyer H, Einspanier R 1998 Growth factors and components for extracellular proteolysis are differentially expressed during in vitro maturation of bovine cumulus-oocyte complexes. Biol Reprod 59:801-806

Dirsch VM, Wolf E, Wanke R, Schulz R, Hermanns W, Vollmar AM 1998 Effect of chronic GH overproduction on cardiac ANP expression and circulating ANP levels. Mol Cell Endocrinol 144:109-118

Durcova-Hills G, Prelle K, Müller S, Stojkovic M, Motlik J, Wolf E, Brem G 1998 Primary culture of porcine PGCs requires LIF and porcine membrane-bound stem cell factor. Zygote 6:271-275

Hoeflich A, Schmidt P, Föll J, Rottmann O, Weber MM, Kolb HJ, Pirchner F, Wolf E 1998 Altered growth of mice divergently selected for body weight is associated with complex changes in the growth hormone/insulin-like growth factor system. Growth Horm IGF Res 8:113-123

Hoeflich A, Lahm H, Blum W, Kolb H, Wolf E 1998 Insulin-like growth factor-binding protein-2 inhibits proliferation of human embryonic kidney fibroblasts and of IGF-responsive colon carcinoma cell lines. FEBS Lett 434:329-334

Kölle S, Sinowatz F, Boie G, Lincoln D, Palma G, Stojkovic M, Wolf E 1998 Topography of growth hormone receptor expression in the bovine embryo. Histochem Cell Biol 109:417-419

Lahm H, Hoeflich A, Rieger N, Wanke R, Wolf E 1998 Identification of transgenic mice by direct PCR analysis of lysates of epithelial cells obtained from the inner surface of the rectum. Transgenic Res 7:131-134

Mepham TB, Combes RD, Balls M, Barbieri O, Blokhuis HJ, Costa P, Crilly RE, de Cock Buning T, Delpire VC, O'Hare MJ, Houdebine LM, van Kreijl CF, van der Meer M, Reinhardt CA, Wolf E, van Zeller AM 1998 The use of transgenic animals in the European Union: the report and recommendations of ECVAM Workshop 28. Altern Lab Anim 26:21-43

Ogiolda L, Wanke R, Rottmann O, Hermanns W, Wolf E 1998 Intestinal dimensions of mice divergently selected for body weight. Anat Rec 250:292-299

Osterrieder N, Wolf E 1998 Lessons from gene knockouts. Rev Sci Tech 17:351-364

Santl B, Wenigerkind H, Schernthaner W, Mödl J, Stojkovic M, Prelle K, Holtz W, Brem G, Wolf E 1998 Comparison of ultrasound-guided vs laparoscopic transvaginal ovum pick-up (OPU) in simmental heifers. Theriogenology 50:89-100

Steinborn R, Zakhartchenko V, Wolf E, Müller M, Brem G 1998 Non-balanced mix of mitochondrial DNA in cloned cattle produced by cytoplast-blastomere fusion. FEBS Lett 426:357-361

Steinborn R, Zakhartchenko V, Jelyazkov J, Klein D, Wolf E, Müller M, Brem G 1998 Composition of parental mitochondrial DNA in cloned bovine embryos. FEBS Lett 426:352-356

Stojkovic M, Büttner M, Zakhartchenko V, Brem G, Wolf E 1998 A reliable procedure for differential staining of in vitro produced bovine blastocysts: comparison of tissue culture medium 199 and Menezo's B2 medium. Anim Reprod Sci 50:1-9

Wolf E, Hoeflich A, Lahm H 1998 What is the function of IGF-II in postnatal life? Answers from transgenic mouse models. Growth Horm IGF Res 8:185-193

Wolf E, Zakhartchenko V, Brem G 1998 Nuclear transfer in mammals: recent developments and future perspectives. J Biotechnol 65:99-110

Zinovieva N, Lassnig C, Schams D, Besenfelder U, Wolf E, Müller S, Frenyo L, Seregi J, Müller M, Brem G 1998 Stable production of human insulin-like growth factor 1 (IGF-1) in the milk of hemi- and homozygous transgenic rabbits over several generations. Transgenic Res 7:437-447

Blackburn A, Dressendorfer RA, Blum WF, Erhard M, Brem G, Strasburger CJ, Wolf E 1997 Interactions of insulin-like growth factor (IGF)-II and growth hormone in vivo: circulating levels of IGF-I and IGF-binding proteins in transgenic mice. Eur J Endocrinol 137:701-708

Blackburn A, Schmitt A, Schmidt P, Wanke R, Hermanns W, Brem G, Wolf E 1997 Actions and interactions of growth hormone and insulin-like growth factor-II: body and organ growth of transgenic mice. Transgenic Res 6:213-222

Stojkovic M, Wolf E, Van Langendonckt A, Vansteenbrugge A, Charpigny G, Reinaud P, Gandolfi F, Brevini TA, Mermillod P, Terqui M, Brem G, Massip A 1997 Correlations between chemical parameters, mitogenic activity and embryotrophic activity of bovine oviduct-conditioned medium. Theriogenology 48:659-673

Stojkovic M, Zakhartchenko V, Brem G, Wolf E 1997 Support for the development of bovine embryos in vitro by secretions of bovine trophoblastic vesicles derived in vitro. J Reprod Fertil 111:191-196

Wolf E, Jehle PM, Weber MM, Sauerwein H, Daxenberger A, Breier BH, Besenfelder U, Frenyo L, Brem G 1997 Human insulin-like growth factor I (IGF-I) produced in the mammary glands of transgenic rabbits: yield, receptor binding, mitogenic activity, and effects on IGF-binding proteins. Endocrinology 138:307-313

Zakhartchenko V, Stojkovic M, Brem G, Wolf E 1997 Karyoplast-cytoplast volume ratio in bovine nuclear transfer embryos: effect on developmental potential. Mol Reprod Dev 48:332-338

Airaksinen MS, Koltzenburg M, Lewin GR, Masu Y, Helbig C, Wolf E, Brem G, Toyka KV, Thoenen H, Meyer M 1996 Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation. Neuron 16:287-295

Förster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M 1996 A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87:1037-1047

Mödl J, Reichenbach HD, Wolf E, Brem G 1996 Development of frozen-thawed porcine blastocysts in vitro and in vivo. Vet Rec 139:208-210

Peters M, Jacobs S, Ehlers M, Vollmer P, Müllberg J, Wolf E, Brem G, Meyer zum Büschenfelde KH, Rose-John S 1996 The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6. J Exp Med 183:1399-1406

Sendtner M, Götz R, Holtmann B, Escary JL, Masu Y, Carroll P, Wolf E, Brem G, Brület P, Thoenen H 1996 Cryptic physiological trophic support of motoneurons by LIF revealed by double gene targeting of CNTF and LIF. Curr Biol 6:686-694

Zakhartchenko V, Reichenbach HD, Riedl J, Palma GA, Wolf E, Brem G 1996 Nuclear transfer in cattle using in vivo-derived vs. in vitro-produced donor embryos: effect of developmental stage. Mol Reprod Dev 44:493-498

Hoeflich A, Wolf E, Braulke T, Koepf G, Kessler U, Brem G, Rascher W, Blum W, Kiess W 1995 Does the overexpression of pro-insulin-like growth factor-II in transfected human embryonic kidney fibroblasts increase the secretion of lysosomal enzymes? Eur J Biochem 232:172-178

Korte M, Carroll P, Wolf E, Brem G, Thoenen H, Bonhoeffer T 1995 Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc Natl Acad Sci U S A 92:8856-8860

Stojkovic M, Wolf E, Büttner M, Berg U, Charpigny G, Schmitt A, Brem G 1995 Secretion of biologically active interferon tau by in vitro-derived bovine trophoblastic tissue. Biol Reprod 53:1500-1507

Wolf E, Rapp K, Blum WF, Kolb H, Brem G 1995 Skeletal growth of transgenic mice with elevated levels of circulating insulin-like growth factor-II. Growth Regul 5:177-183

Wolf E, Wanke R, Schenck E, Hermanns W, Brem G 1995 Effects of growth hormone overproduction on grip strength of transgenic mice. Eur J Endocrinol 133:735-740

Zakhartchenko V, Wolf E, Palma GA, Brem G 1995 Effect of donor embryo cell number and cell size on the efficiency of bovine embryo cloning. Mol Reprod Dev 42:53-57

Brem G, Hartl P, Besenfelder U, Wolf E, Zinovieva N, Pfaller R 1994 Expression of synthetic cDNA sequences encoding human insulin-like growth factor-1 (IGF-1) in the mammary gland of transgenic rabbits. Gene 149:351-355

Wolf E, Kramer R, Blum WF, Föll J, Brem G 1994 Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth. Endocrinology 135:1877-1886

Wolf E, Kramer R, Polejaeva I, Thoenen H, Brem G 1994 Efficient generation of chimaeric mice using embryonic stem cells after long-term culture in the presence of ciliary neurotrophic factor. Transgenic Res 3:152-158

Masu Y, Wolf E, Holtmann B, Sendtner M, Brem G, Thoenen H 1993 Disruption of the CNTF gene results in motor neuron degeneration. Nature 365:27-32

Wolf E, Kahnt E, Ehrlein J, Hermanns W, Brem G, Wanke R 1993 Effects of long-term elevated serum levels of growth hormone on life expectancy of mice: lessons from transgenic animal models. Mech Ageing Dev 68:71-87

Wanke R, Wolf E, Hermanns W, Folger S, Buchmüller T, Brem G 1992 The GH-transgenic mouse as an experimental model for growth research: clinical and pathological studies. Horm Res 37 Suppl 3:74-87

Brem G, Brenig B, Salmons B, Wolf E, Müller M, Erfle V, Gunzburg WH, Dahme E 1991 [Unexpected transgene expression of a mammary-specific growth hormone gene construct in Bergmann glial cells of the mouse]. Tierarztl Prax 19:345-350

Wanke R, Hermanns W, Folger S, Wolf E, Brem G 1991 Accelerated growth and visceral lesions in transgenic mice expressing foreign genes of the growth hormone family: an overview. Pediatr Nephrol 5:513-521

Wolf E, Brem G 1991 "High-dose hook effect" as a pitfall in quantifying transgene expression in metallothionein-human growth hormone (MT-hGH) transgenic mice. Clin Chem 37:763-765

Wolf E, Rapp K, Brem G 1991 Expression of metallothionein-human growth hormone fusion genes in transgenic mice results in disproportionate skeletal gigantism. Growth Dev Aging 55:117-127

Wolf E, Rapp K, Wanke R, Hermanns W, Pirchner F, von Butler-Wemken I, Brem G 1991 Growth characteristics of metallothionein-human growth hormone transgenic mice as compared to mice selected for high eight-week body weight and unselected controls. II. Skeleton. Growth Dev Aging 55:237-248

Wolf E, Wanke R, Hermanns W, Brem G, Pirchner F, von Butler-Wemken I 1991 Growth characteristics of metallothionein-human growth hormone transgenic mice as compared to mice selected for high eight-week body weight and unselected controls. I. Body weight gain and external body dimensions. Growth Dev Aging 55:225-235

Brem G, Wanke R, Wolf E, Buchmuller T, Müller M, Brenig B, Hermanns W 1989 Multiple consequences of human growth hormone expression in transgenic mice. Mol Biol Med 6:531-547